Abstract

Short Communication

Screening for BK Virus Infection in Kidney Transplant Recipients at Mohamed V Military Teaching Hospital

O Skalante, S Elkochri, FZ Adil, M Hachimi Idrissi, Y Aadi, Y Elbenaissi, A Bahadi, MR Tagajdid, H Elannaz, A Laraqui, B Elmchichi, N Touil, K Ennibi, I Lahlou Amine and R Abi*

Published: 25 July, 2024 | Volume 8 - Issue 2 | Pages: 024-025

After kidney transplantation, BK polyomavirus reactivation can manifest as nephropathy in 1% to 10% of patients. PCR testing of urine and blood is commonly used to screen for BK polyomavirus nephropathy. The study aims to detect BK virus infection in kidney transplant patients to prevent tubulointerstitial nephropathy and graft loss. This retrospective study includes 26 patients who underwent kidney transplants between January 2019 and December 2023. We diagnosed BK virus infection by performing real-time PCR on blood and urine samples. BKV DNA was detected in 3 patients. Reducing immunosuppressive therapy led to negative PCR results and favorable clinical and biological outcomes in these 3 patients.

Read Full Article HTML DOI: 10.29328/journal.ijcv.1001058 Cite this Article Read Full Article PDF

Keywords:

BK Virus; Kidney transplant; PCR

References

  1. Kant S, Dasgupta A, Bagnasco S, Brennan DC. BK Virus Nephropathy in Kidney Transplantation: A State-of-the-Art Review. Viruses. 2022 Jul 25;14(8):1616. Available from: https://doi.org/10.3390/v14081616
  2. McCaffrey J, Bhute VJ, Shenoy M. BK virus infection and outcome following kidney transplantation in childhood. Sci Rep. 2021;11:2468. Available from: https://www.nature.com/articles/s41598-021-82160-0
  3. Liu Y, Kong C, Hu H, Zhang Y, Wang T, Qiu T, Zhou J. Risk factors for BK virus infection in DCD donor kidney transplant recipients. Front Med (Lausanne). 2023;10:1181743. Available from: https://doi.org/10.3389%2Ffmed.2023.1181743
  4. Hirsch HH, Knowles W, Dickenmann M, Dickenmann M, Passweg J, Klimkait T, et al. Prospective study of polyoma type BK replication and nephropathy in renal transplant recipients. N Engl J Med. 2002;347(7):488-496. Available from: https://www.nejm.org/doi/full/10.1056/NEJMoa020439
  5. Mark DI, Ward K, Howe J, Barret AJ, Goldman JM. Viral (polyoma) cystitis heralding cytomegalovirus infection. Lancet. 1992;339(8795):1122-1123.
  6. Pinto GG, Poloni JAT, Paskulin DD, Spuldaro F, Paris F, Barth AL, et al. Quantitative detection of BK virus in kidney transplant recipients: a prospective validation study. J Bras Nefrol. 2018 Jan-Mar;40(1):59-65. Available from: https://doi.org/10.1590/1678-4685-jbn-3776

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