Frequency of cytomegalovirus infection in children with Nephrotic Syndrome
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Abstract
Introduction and aim: Idiopathic nephrotic syndrome (INS) is the most common type of this disease during childhood. Minimal change nephrotic syndrome (MCNS) is the most common histopathological lesion (80 – 90%) of INS in children and about 90% of patients are steroid responsive, while congenital nephrotic syndrome is disorder that may be caused by several diseases. Intrauterine infections, especially CMV infection, have frequently been incriminated as etiological factors of secondary CNS. The aim of this research was to evaluate the frequency of CMV infection children with active nephrotic syndrome in our pediatric nephrology unit
Patients and methods: This descriptive (cross sectional) study was conducted in pediatric nephrology unit, Zagazig University Hospitals and included 60 patients WITH NS in activity; Participants were subjected to, Full history taking, Clinical examination; general & local, Routine laboratory investigations and Serum samples were tested for HCMV specific immunoglobulin G (IgG) and immunoglobulin M (IgM) using ELISA Kit.
Results: We found 100% of cases were IgG positive and 7/60 cases were IgM positive, There were no statistically significant differences between IgM positive-patients vs IgM-negative patients according to age, sex and first attack or relapsed NS, There were statistically significant differences between IgM positive-patients vs IgM-negative patients in blood laboratory data in decreases in HB (P=0.024) and serum urea nitrogen (P=0.04)
Conclusion: We concluded that serofrequency of cytomegalovirus infection in pediatric nephrology unit, Zagazig university hospitals during follow-up was 12% for cmv IgM and 100% for cmv IgG at ns children patients
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Bagga A, Mantan m. Nephrotic syndrome in children. Indian J Med Res. 2005; 122: 13–28. Ref.: https://tinyurl.com/yxaccv35
Manicklal S, Emery VC, Lazzarotto T, Boppana SB, Gupta RK. The ‘Silent’ Global Burden of Congenital Cytomegalovirus. Clin Microbiol Rev. 2013; 26: 86–102. Ref.: https://tinyurl.com/y3g5tc26
Nigro G, Anceschi MM, Cosmi EV. Congenital Cytomegalic Disease Collaborating Group. Clinical manifestations and abnormal laboratory findings in pregnant women with primary cytomegalovirus infection. BJOG. 2003; 110: 572–577. Ref.: https://tinyurl.com/y6cqt6qw
Revello MG, Gerna G. Diagnosis and Management of Human Cytomegalovirus Infection in the Mother, Fetus, and Newborn Infant. Clin Microbiol Rev. 2002; 15: 680–715. Ref.: https://tinyurl.com/yxf5z66n
Schleiss MR. Acquisition of human cytomegalovirus infection in infants via breast milk: natural immunization or cause for concern? Rev Med Virol. 2006; 16: 73–82. Ref.: https://tinyurl.com/y4do6exc
Centers for Disease Control and Prevention, Cytomegalovirus and congenital Infection—Interpretation of laboratory tests.2014.
Cohen JI. Epstein–Barr Virus Infection. N Engl J Med. 2000; 343: 481-492. Ref.: https://tinyurl.com/yyeo98gy
Niaudet P, Boyer O. Idiopathic Nephrotic Syndrome in Children: Clinical Aspects. Pediat Nephrol. 2009; 667–702. Ref.: https://tinyurl.com/y5y754zy
Giani M, Edefonti A, Damiani B, Marra G, Colombo D, et al. Nephrotic syndrome in a mother and her infant: relationship with cytomegalovirus infection. Pediatr Nephrol. 10; 1996: 73–75. Ref.: https://tinyurl.com/y6opevt8
Besbas N, Bayrakci US, Kale G, Cengiz AB, Akcoren Z, et al. Cytomegalovirus-related congenital nephrotic syndrome with diffuse mesangial sclerosis. Pediatr Nephrol. 2006’ 201: 740-742. Ref.: https://tinyurl.com/yypr3nvr
Soares SF, Donatti TL, Souto FJ. Serological Markers of Viral, Syphilitic and Toxoplasmic Infection in Children and Teenagers With Nephrotic Syndrome: Case Series From Mato Grosso State, Brazil. Rev Inst Med Trop Sao Paulo. 2014; 56: 499–504. Ref.: https://tinyurl.com/y5t93wah
Vachvanichsanong P, Mitarnun W, Tungsinmunkong K, Dissaneewate P. Congenital and Infantile Nephrotic Syndrome in Thai Infants. Clin Pediat. 2005; 44: 169–174. Ref.: https://tinyurl.com/y3jaesbk
Poyrazoglu HM, Dursun I, Bastug F, Gunduz Z, Akyildiz BN, et al. Cytomegalovirus infection and haemophagocytosis in a patient with congenital nephrotic syndrome. Pediatr Nephrol. 2009; 254: 2257–2259. Ref.: https://tinyurl.com/y26yyuq7