Figure 2

ACE2 and TMPRSS2 polymorphisms and the development of COVID-19: a review of the literature

Adrhyan Araújo da Silva Oliveira, Ana Maisa Passos da Silva, Jackson Alves da Silva Queiroz, Paulo Ricardo Freitas de Souza, Juan Miguel Villalobos Salcedo and Deusilene Souza Vieira*

Published: 28 April, 2022 | Volume 6 - Issue 1 | Pages:


Figure 2:

Renin-Angiotensin Aldosterone System (RAAS). 
Subtitle: Angiotensinogen is secreted by the liver, then the adrenal glands secrete the enzyme Renin which cleaves it into Angiotensin I (ANG I), subsequently Ang I can be cleaved either by ACE → Ang II or by ACE2 which can transform it into angiotensin 1-9 or angiotensin 1-7. SARS-CoV-2 can promote a higher concentration of Ang II, as the interaction with ACE2 internalizes it in the cytoplasm of the cell preventing it from performing its physiological function, with this Ang II can bind to ATR1 causing hypertension.

Read Full Article HTML DOI: 10.29328/journal.ijcv.1001044 Cite this Article Read Full Article PDF

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