Published: 16 February, 2021 | Volume 5 - Issue 1 | Pages: 022-031
Ultrastructural- features of severe acute respiratory syndrome – SARS coronavirus 2 lung- infection in fatal coronavirus disease. A) Top: alveolar space containing extracellular virions (arrows) with prominent surface projections. Bottom: cluster of virions in the alveolar- space ( A. S.). Scale bars indicate 200 nm. B) Extracellular virions (arrow) associated with ciliated cells of the upper airway. Scale bar indicates 200 nm. C) Membrane-bound vacuoles (arrows) containing viral- particles within the cytoplasm of an infected type II pneumocyte; surfactant (lamellated -material) indicted by arrowheads. Scale bar indicates 1 μm. D) Membrane-bound vacuole (double-headed arrow in panel C) containing virus -particles (arrows) with the characteristic black dots that are cross-sections through the viral nucleocapsid. Arrowheads indicate vacuolar- membrane. Scale bar indicates 200 nm. E) Viral particles (arrow) within a phagosome of an alveolar macrophage. Scale bar: 200 nm. F) Viral particles within a portion of a hyaline- membrane. Scale bar indicates 800 nm. Inset: Higher magnification of virus- particles indicated by arrow; scale bar indicates 200 nm. Image from Vol-26, Number 9—September 2020 Synopsis.