Abstract

Short Review

The Psychology of the Common Cold and Influenza: Implications for COVID-19

Andrew P Smith*

Published: 20 April, 2020 | Volume 4 - Issue 1 | Pages: 027-031

Research on psychological risk factors for upper respiratory tract illnesses (URTIs) has been conducted for over fifty years. Early studies failed to control for exposure and also often relied on self-report rather than clinical and virological assessment. A universal policy used in the current COVID-19 pandemic has been to restrict exposure by social isolation. This leads to increased stress and removal of social interaction. In addition, information overload about the disease, and incorrect information, can also reduce wellbeing. Studies of experimentally-induced URTIs have shown that stress increases susceptibility to infection. Other research has shown that stress due to job insecurity and few social contacts are key risk factors for infection. This suggests that while social isolation will reduce exposure, it will also lead to an increased risk of illnesses, due to increased stress and reduced social support, should the person become infected with the virus. Other research has shown that infection and illness lead to changes in behaviour. These effects include greater negative affect and impaired attention and slower speed of response. Such effects are not only present when the person is symptomatic but also occur with sub-clinical infections, during the incubation period and after the illness. People with the illness are also more sensitive to other negative influences such as fatigue, and this has implications for safety critical jobs such as those carried out by healthcare professionals treating those with COVID-19.

Read Full Article HTML DOI: 10.29328/journal.ijcv.1001011 Cite this Article Read Full Article PDF

References

  1. Cohen S, Williamson GM. Stress and infectious disease in humans. Psychol Bull. 1991; 109: 05–24. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/2006229
  2. Brooks K, Webster RK, Smith LE, Woodland L, Wessely S, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. The Lancet. 2020; 395: 912-920.
  3. Fan J, Smith AP. (in preparation). Information overload, wellbeing and COVID-19: A survey in China.
  4. Lai J, Ma S, Wang Y, Cai Z, Hu J, et al. Factors associated with mental health outcomes among healthcare workers exposed to Coronavirus Disease 2019. JAMA Netw Open. 2020; 3: e203976. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/32202646
  5. Cohen S, Tyrrell DA, Smith AP. Psychological stress in humans and susceptibility to the common cold. N Engl J Med. 1991; 325: 606 - 612. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1713648
  6. Cohen S, Tyrrell DA, Russell MA, Jarvis MJ, Smith AP. Smoking, alcohol consumption and susceptibility to the common cold. Am J Public Health. 1993; 83: 1277-1283. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8363004
  7. Cohen S, Tyrrell DA, Smith AP. Negative Life Events, Perceived Stress, Negative Affect and Susceptibility to the Common Cold. J Pers Soc Psychol. 1993; 64: 131 -140. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/8421249
  8. Smith A, Nicholson K. Psychosocial factors, respiratory viruses and exacerbation of 2020, asthma. Psychoneuroendocrinology. 2001; 26: 411-420. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/11259860
  9. Song H, Fall K, Fang F, Erlendsdóttir H, Lu D, et al. Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study. BMJ. 2019; 367: 15784. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/31645334
  10. Cohen S. Keynote Presentation at the Eight International Congress of Behavioral Medicine: the Pittsburgh common cold studies: psychosocial predictors of susceptibility to respiratory infectious illness. Int J Behav Med. 2005; 12: 123-131. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16083315
  11. Cohen S, Doyle WJ, Skoner DP, Fireman P, Gwaltney JM Jr, et al. State and trait negative affect as predictors of objective and subjective symptoms of respiratory viral infections. J Pers Soc Psychol. 1995, 68, 159-169. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/7861312
  12. Cohen S, Line S, Manuck SB, Rabin BS, Heise ER, et al. Chronic social stress, social status and susceptibility to upper respiratory infections in nonhuman primates. Psychosom Med. 1997; 59: 213-221. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/9254393
  13. Cohen S, Doyle WJ, Skoner DP, Rabin BS, Gwaltney JM Jr. Social ties and susceptibility to the common cold. JAMA. 1997; 277: 1940-1944. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/9200634
  14. Cohen S, Frank E, Doyle WJ, Skoner DP, Rabin BS, et al. Types of stressors that increase susceptibility to the common cold in healthy adults. Health Psychol. 1998; 17: 214-223. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/9619470
  15. Cohen S, Doyle WJ, Skoner DP. Psychological stress, cytokine production, and severity of upper respiratory illness. Psychosom Med. 1999; 61: 175-180. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/10204970
  16. Cohen S, Doyle WJ, Turner RB, Alper CM, Skoner DP. Childhood socioeconomic status and host resistance to infectious illness in adulthood. Psychosom Med. 2004, 66, 553-558. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/15272102
  17. Cohen S, Alper CM, Doyle WJ, Treanor JJ, Turner RB. Positive emotional style predicts resistance to illness after experimental exposure to rhinovirus or influenza A virus. Psychosom Med. 2006; 68: 809-815. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17101814
  18. Doyle WJ, Gentile DA, Cohen S. Emotional style, nasal cytokines, and illness expression after experimental rhinovirus exposure. Brain Behav Immun. 2007; 20”: 175-181. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/16023829
  19. Janicki-Deverts D, Cohen S, Doyle WJ, Turner RB, Treanor JJ. Infection-induced proinflammatory cytokines are associated with decreases in positive affect, but not increases in negative affect. Brain Behav Immun. 2007; 21: 301-307. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/17055218
  20. Doyle WJ, Casselbrant ML, Li-Korotky H, Cullen Doyle AP, Lo C, et al. The interleukin 6 -174 C/C genotype predicts greater rhinovirus illness. J Infectious Dis. 2010; 201: 199-206.
  21. Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A. 2012; 109: 5995-5999. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22474371
  22. Cohen S, Janicki-Deverts D, Turner RB, Casselbrant ML, Li-Korotky HS, et al. Association between telomere length and experimentally induced upper respiratory viral infection in healthy adults. JAMA. 2013; 309: 699-705. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23423415
  23. Cohen S, Janicki-Deverts D, Turner RB, Marsland AL, Casselbrant ML, et al. Childhood socioeconomic status, telomere length, and susceptibility to upper respiratory infection. Brain Behav Immun. 2013l 34: 31-38. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23845919
  24. Cohen S, Janicki-Deverts D, Turner RB, Doyle WJ. Does hugging provide stress-buffering social support? A study of susceptibility to upper respiratory infection and illness. Psychol Sci. 2015; 26: 135-147. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/25526910
  25. Prather AA, Janicki-Deverts D, Hall MH, Cohen S. Behaviorally assessed sleep and susceptibility to the common cold. Sleep. 2015; 38: 1353-1359. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26118561
  26. Cohen S, Janicki-Deverts D, Doyle WJ. Self-rated health in healthy adults and susceptibility to the common cold. Psychosom Med. 2015; 77: 959-968. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26397938
  27. Janicki-Deverts D, Cohen S, Turner RB, Doyle WJ. Basal salivary cortisol secretion and susceptibility to upper respiratory infection. Brain Behav Immun. 2016; 53: 255-261. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/26778776
  28. Miller GE, Cohen S, Janicki-Deverts D, Brody GH, Chen E. Viral challenge reveals further evidence of skin-deep resilience in African Americans from disadvantaged backgrounds. Health Psychology. 2016; 35: 1225-1234. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27505193
  29. Janicki Deverts D, Cohen S, Doyle WJ. Dispositional affect moderates the stress-buffering effect of social support on risk for developing the common cold. J Pers 2017; 85: 675-686. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27468129
  30. Murphy MLM, Cohen S, Janicki-Deverts D, Doy le WJ. Offspring of parents who were separated and not speaking to one another have reduced resistance to the common cold as adults. Proc Natl Acad Sci U S A. 2017; 114: 6515-6520. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/28584098
  31. Prather AA, Janicki-Deverts D, Adler NE, Hall M, Cohen S. Sleep habits and susceptibility to upper respiratory illness: the moderating role of subjective socioeconomic status. Ann Behav Med. 2017; 51: 137-146. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/27679462
  32. Cohen S, Janicki-Deverts D, Doyle WJ, Miller GE, Frank E, et al. Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk. Proc Natl Acad Sci U S A. 2012; 109: 5995–5999. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/22474371
  33. Pedersen AF, Zachariae R, Bovbjerg DH. Psychological stress and antibody response to influenza vaccination: A meta-analysis. Brain Behav Immun. 2009; 23: 427-460. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/19486657
  34. Hewson-Bower B, Drummond PD. Psychological treatment for recurrent symptoms of colds and flu in children. J Psychosom Res. 2001; 51: 369-377. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/11448705
  35. Smith AP. Twenty-five years of research on the behavioural malaise associated with influenza and the common cold. Psychoneuroendocrinology. 2013; 38: 744-751. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/23021498
  36. Smith AP, Tyrrell DA, Coyle K, Willman JS. Selective effects of minor illnesses on human performance. Brit J Psychol. 1987; 78: 183 - 188. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3594089
  37. Smith AP, Tyrrell DA, Al-Nakib W, Coyle KB, Donovan CB, et al. Effects of experimentally-induced virus infections and illnesses on psychomotor performance. Neuropsychobiology. 1987; 18: 144-148. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3453430
  38. Smith AP, Tyrrell DA, Al-Nakib W, Coyle KB, Donovan CB, et al. The effects of experimentally-induced respiratory virus infections on performance. Psychol Med. 1988; 18: 65 - 71. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/3363045
  39. Smith AP, Tyrrell DA, al-Nakib W, Barrow PG, Higgins PG, et al. Effects and after-effects of the common cold and influenza on human performance. Neuropsychobiology. 1989; 21: 90 - 93. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/2559360
  40. Smith AP, Tyrrell DA, Barrow GI, Coyle KB, Higgins PG, et al. The effects of experimentally induced colds on aspects of memory. Percept Mot Skills. 1990; 71: 1207 - 1215. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1965023
  41. Smith AP, Tyrrell DAJ, Barrow GI, Higgins PG, Willman JS, et al. Mood and experimentally-induced respiratory virus infections and illnesses. Psychol Health. 1992; 6: 205-212.
  42. Smith AP, Tyrrell DA, Barrow GI, Higgins PG, Bull S, et al. The Common Cold, pattern sensitivity and contrast sensitivity. Psychol Med. 1992l 22: 487-494. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/1319599
  43. Poyiadji N, Shahin G, Noujaim D, Stone M, Patel S, et al. COVID-19–associated Acute Hemorrhagic Necrotizing Encephalopathy: CT and MRI. Radiology. 2020; 201187. PubMed: https://www.ncbi.nlm.nih.gov/pubmed/32228363

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